Between the top of the arm bone (humerus) and the bony arch above it (the acromion) lies a narrow space called the subacromial space. The rotator cuff tendons and the subacromial bursa (a small fluid-filled sac that reduces friction) pass through this space. When the space becomes narrowed, due to inflammation, bone spurs, or changes in the mechanics of the shoulder, these structures can become pinched or irritated with arm movement, particularly when lifting the arm overhead.